THIP
THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 µM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders.
| Trivial name | Gaboxadol |
| Catalog Number | E8100 |
| Molecular Formula | C28H32O15 |
| CAS# | 64603-91-4 |
| Inchi | InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21 -,22+,23+,24-,25+,26+,27+,28+/m0/s1 |
| Inchi Key | GZSOSUNBTXMUFQ-YFAPSIMESA-N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/thip.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8100-thip-chemical-structure-tube.png |