ML218
ML218 is a potent, selective, and orally active inhibitor of T-type Ca²⁺ channels (Cav3.1, Cav3.2, and Cav3.3), with IC50 of 310 nM for Cav3.2 and 270 nM for Cav3.3. It effectively suppresses burst activity in subthalamic nucleus (STN) neurons.
| Catalog Number | E8077 |
| Molecular Formula | C22H25NO6 |
| CAS# | 1346233-68-8 |
| Inchi | InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1 |
| Inchi Key | IAKHMKGGTNLKSZ-INIZCTEOSA-N |
| SMILES | CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/ml218.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E8077-ML218-chemical-structure.png |