ML 145
ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM). ML 145 has no significant activity for GPR35 at either rodent ortholog.
| Catalog Number | E8014 |
| Molecular Formula | C18H21F3N6O2 |
| CAS# | 1164500-72-4 |
| Inchi | InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23) |
| Inchi Key | CWHUFRVAEUJCEF-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ml-145.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8014-ml-145-chemical-structure-tube.png |