Ro 90-7501
Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells.
| Catalog Number | E7917 |
| Molecular Formula | C23H24FN6O9P.2Na |
| CAS# | 293762-45-5 |
| Inchi | InChI=1S/C23H26FN6O9P.2Na/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,2 9);;/q;2*+1/p-2 |
| Inchi Key | HSYBQXDGYCYSGA-UHFFFAOYSA-L |
| SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+] |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ro-90-7501.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7917-ro-90-7501-chemical-structure-tube.png |