GNE-272
GNE-272 is a potent and selective CBP/EP300 inhibitor with IC50 values of 0.02, 0.03 and 13 μM for CBP, EP300 and BRD4, respectively. GNE-272 is also a selective in vivo probe for CBP/EP300.
| Catalog Number | E7864 |
| Molecular Formula | C20H23BCl2N2O9 |
| CAS# | 1936428-93-1 |
| Inchi | InChI=1S/C20H23BCl2N2O9/c1-10(2)5-14(21-33-17(29)8-20(34-21,19(31)32)7-16(27)28)25-15(26)9-24-18(30)12-6-11(22)3-4-13(12)23/h3-4,6,10,14H,5,7-9H2,1-2H3,(H,24,30)(H,25,26)(H,27,28)(H,31,32)/t14-,20?/m0 /s1 |
| Inchi Key | YTXSYWAKVMZICI-PVCZSOGJSA-N |
| SMILES | B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)C(CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/gne-272.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7864-gne-272-chemical-structure-tube.png |