CKI-7
CKI-7 (CKI-7 2HCl) is an inhibitor of casein kinase 1 (CK1) with ki of 8.5 μM and IC50 of 6 μM. It is selective for CK1 over CK2, PKC, CaM kinase II (CaMKII), and cyclic AMP-dependent protein kinase (PKA) with IC50 of 90, >1000, 195, and 550 μM, respectively. It also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1).
| Trivial name | CKI-7 2HCl |
| Catalog Number | E7852 |
| Molecular Formula | C6H6Cl2N2O4S2 |
| CAS# | 1177141-67-1 |
| Inchi | InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) |
| Inchi Key | GJQPMPFPNINLKP-UHFFFAOYSA-N |
| SMILES | C1=C(C=C(C(=C1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/cki-7.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7852-CKI-7-chemical-structure.png |