Cot inhibitor-1
Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC50 of 5.7 nM.
Catalog Number | E7798 |
Molecular Formula | C30H29ClN6O3 |
CAS# | 915365-57-0 |
Inchi | InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9- 7+ |
Inchi Key | JWNPDZNEKVCWMY-VQHVLOKHSA-N |
SMILES | CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C |
Size | 1mg |
Supplier Page | http://www.selleckchem.com/products/cot-inhibitor-1.html |
Additional Information | https://file.selleck.cn/downloads/struct/e7798-cot-inhibitor-1-chemical-structure-tube.png |