Siramesine
Siramesine (Lu 28-179) is a potent agonist of sigma-2 receptor(σ1R) with an IC50 of 0.12 nM, exhibiting 140-fold selectivity over sigma-1 receptors. It shows strong anxiolytic effects and induces cancer cell death, highlighting its potential anticancer activity.
| Trivial name | Lu 28-179 |
| Catalog Number | E7744 |
| Molecular Formula | C17H20ClN3O3.HCl |
| CAS# | 147817-50-3 |
| Inchi | InChI=1S/C17H20ClN3O3.ClH/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21;/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23);1H |
| Inchi Key | DBMKBKPJYAHLQP-UHFFFAOYSA-N |
| SMILES | CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4.Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/siramesine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7744-Siramesine-chemical-structure.png |