7-Chlorokynurenic acid

7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.

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Trivial name	7-CKA
Catalog Number	E7707
Molecular Formula	C8H15N7O2S3
CAS#	18000-24-3
Inchi	InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
Inchi Key	XUFQPHANEAPEMJ-UHFFFAOYSA-N
SMILES	C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N
Size	5mg
Supplier Page	http://www.selleckchem.com/products/7-chlorokynurenic-acid.html
Additional Information	https://file.selleck.cn/downloads/struct/e7707-7-chlorokynurenic-acid-chemical-structure-tube.png