Azimilide
Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.IC50 value:Target: in vitro: Azimilide blocked HERG channels at 0.1 and 1 Hz with IC50s of 1.4 microM and 5.2 microM respectively. Azimilide blockade of HERG channels expressed in Xenopus oocytes and I(Kr) in mouse AT-1 cells was decreased under conditions of high [K+]e, whereas block of slowly activating I(Ks) channels was not affected by changes in [K+]e . Azimilide suppressed the following currents (Kd in parenthesis): IKr (< 1 microM at -20 mV), IKs (1.8 microM at +30 mV), L-type Ca current (17.8 microM at +10 mV), and Na current (19 microM at -40 mV). Azimilide was a
| Trivial name | NE-10064 |
| Catalog Number | E7668 |
| Molecular Formula | C9H13N3O5 |
| CAS# | 149908-53-2 |
| Inchi | InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 |
| Inchi Key | UHDGCWIWMRVCDJ-XVFCMESISA-N |
| SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/azimilide.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7668-azimilide-chemical-structure-tube.png |