Mardepodect
Mardepodect is a potent, orally active, and selective inhibitor of PDE10A with an IC50 of 0.37 nM and >1000-fold selectivity over other phosphodiesterases. It also suppresses microglial activation in LPS-induced neuroinflammation and MPTP-induced Parkinson’s disease mouse models.
| Trivial name | PF-2545920 |
| Catalog Number | E7654 |
| Molecular Formula | C9H11FN2O5 |
| CAS# | 898562-94-2 |
| Inchi | InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1 |
| Inchi Key | ZWAOHEXOSAUJHY-ZIYNGMLESA-N |
| SMILES | CC1C(C(C(O1)N2C=C(C(=O)NC2=O)F)O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/mardepodect.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7654-Mardepodect-chemical-structure.png |