Taltobulin
Taltobulin (HTI-286), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis.
| Trivial name | HTI-286, SPA-110 |
| Catalog Number | E7642 |
| Molecular Formula | C13H12N2O5S |
| CAS# | 228266-40-8 |
| Inchi | InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3 |
| Inchi Key | HYWYRSMBCFDLJT-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2 |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/taltobulin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7642-taltobulin-chemical-structure-tube.png |