CCR2 antagonist 4
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.
| Trivial name | Teijin compound 1 |
| Catalog Number | E7618 |
| Molecular Formula | C25H31N7O6 |
| CAS# | 226226-39-7 |
| Inchi | InChI=1S/C21H25N7.C4H6O6/c1-16-14-20(26-25-16)23-19-15-21(28-12-10-27(2)11-13-28)24-18(22-19)9-8-17-6-4-3-5-7-17;5-1(3(7)8)2(6)4(9)10/h3-9,14-15H,10-13H2,1-2H3,(H2,22,23,24,25,26);1-2,5-6H,(H,7,8)(H,9 ,10)/b9-8+;/t;1-,2-/m.1/s1 |
| Inchi Key | KGWWHPZQLVVAPT-STTJLUEPSA-N |
| SMILES | CC1=CC(=NN1)NC2=CC(=NC(=N2)C=CC3=CC=CC=C3)N4CCN(CC4)C.C(C(C(=O)O)O)(C(=O)O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ccr2-antagonist-4.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7618-ccr2-antagonist-4-chemical-structure-tube.png |