HET0016
HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth.
| Catalog Number | E7611 |
| Molecular Formula | C18H17F2N3O2 |
| CAS# | 339068-25-6 |
| Inchi | InChI=1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23) |
| Inchi Key | SCFMWQIQBVZOQR-UHFFFAOYSA-N |
| SMILES | CCCCOC1=C(C=NC2=NNC=C12)C(=O)C3=C(C=C(C=C3F)C)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/het0016.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7611-het0016-chemical-structure-tube.png |