AVN-944
AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research.
| Trivial name | VX-944 |
| Catalog Number | E7526 |
| Molecular Formula | C12H14N2O2 |
| CAS# | 297730-17-7 |
| Inchi | InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16) |
| Inchi Key | DQMZLTXERSFNPB-UHFFFAOYSA-N |
| SMILES | CCC1(C(=O)NCNC1=O)C2=CC=CC=C2 |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/avn-944.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7526-avn-944-chemical-structure-tube.png |