A-674563

A-674563 is a selective, orally active inhibitor of Akt1 with a Ki of 11 nM. It also inhibits PKA with Ki of 16 nM and CDK2 with Ki of 46 nM. A-674563 reduces Akt downstream target phosphorylation and inhibits tumor cell proliferation in vitro with an EC50 of 0.4 µM.

Price Not Available 5mg A-674563 Supplier Page
Catalog Number E7359
Molecular Formula C19H17Cl3N2S.HNO3
CAS# 552325-73-2
Inchi InChI=1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)
Inchi Key ZHPWRQIPPNZNML-UHFFFAOYSA-N
SMILES C1=CC(=C(C(=C1)Cl)SC(CCC2=CC=C(C=C2)Cl)CN3C=CN=C3)Cl.[N+](=O)(O)[O-]
Size 5mg
Supplier Page http://www.selleckchem.com/products/e7359-a-674563.html
Additional Information https://file.selleck.cn/downloads/struct/E7359-A-674563-chemical-structure.png

A-674563 HCl

A-674563 HCl is an Akt1 inhibitor with Ki of 11 nM in cell-free assays, modest potent to PKA and >30-fold selective for Akt1 over PKC.

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Trivial name N/A
Catalog Number S2670
Molecular Formula C11H10N4O
CAS# 2070009-66-2
Inchi InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16)
Inchi Key LMWPVSNHKACEKW-UHFFFAOYSA-N
SMILES C1=CC=C(C(=C1)N)NC(=O)C2=NC=CN=C2
Size 5mg
Supplier Page http://www.selleckchem.com/products/a-674563.html
Additional Information https://file.selleck.cn/downloads/struct/S2670-A-674563-HCl-chemical-structure.png