δ-Tocotrienol
δ-Tocotrienol is a form of vitamin E that disrupts PD-L1 glycosylation by inhibiting the TCF4-STT3 pathway, leading to lower PD-L1 expression and reduced exosomal release. This reduction in PD-L1 impairs the PD-L1/PD-1 interaction, thereby reversing immune suppression. It also inhibits prostate cancer development by reducing cell proliferation, promoting apoptosis, and blocking angiogenesis in Ptenp−/− mice.
| Catalog Number | E7357 |
| Molecular Formula | C53H72N2O12.2(C6H5O3S) |
| CAS# | 25612-59-3 |
| Inchi | InChI=1S/C53H72N2O12.2C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39 )43(55)29-37-15-17-45(59-4)47(31-37)61-6;2*7-10(8,9)6-4-2-1-3-5-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3;2*1-5H,(H,7,8,9)/q+2;;/p-2 |
| Inchi Key | XXZSQOVSEBAPGS-UHFFFAOYSA-L |
| SMILES | C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)[O-].C1=CC=C(C=C1)S(=O)(=O)[O-] |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/delta-tocotrienol.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7357-Delta-Tocotrienol-chemical-structure.png |