7β-Hydroxycholesterol
7β-Hydroxycholesterol is an oxysterol derived from the oxidation of cholesterol. It induces endothelial apoptosis, IL-1β secretion, and oxidative stress, leading to inflammation and organelle dysfunction. It also upregulates ICAM-1, VCAM-1, and E-selectin, thereby enhancing leukocyte adhesion in early atherosclerosis.
Catalog Number | E7230 |
Molecular Formula | C46H62N4O11 |
CAS# | 566-27-8 |
Inchi | InChI=1S/C46H62N4O11/c1-22(2)21-50-18-16-46(17-19-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-20-15-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)23(3)13-12-14-24(4)44(57)47-36(40(32)5 5)35(34)49-46/h12-15,20,22-23,25-27,30,37-38,41,49,52-54H,16-19,21H2,1-11H3,(H,47,57)/b13-12+,20-15+,24-14+/t23-,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1 |
Inchi Key | ATEBXHFBFRCZMA-NYGPAKPVSA-N |
SMILES | CC1C=CC=C(C(=O)N=C2C(=C3C(=C4C2=NC5(N4)CCN(CC5)CC(C)C)C6=C(C(=C3O)C)OC(C6=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)C |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/7beta-hydroxycholesterol.html |
Additional Information | https://file.selleck.cn/downloads/struct/E7230-7beta-Hydroxycholesterol-chemical-structure.png |