Olverembatinib
Olverembatinib (GZD824, HQP1351) is an orally bioavailable inhibitor of pan-Bcr-Abl. It effectively inhibits a wide range of Bcr-Abl mutants, with IC50 of 0.34 nM and 0.68 nM for native Bcr-Abl and the Bcr-AblT315I mutant, respectively. It also induces tumor regression in mouse xenograft models.
| Trivial name | GZD824, HQP1351 |
| Catalog Number | E7062 |
| Molecular Formula | C7H6ClN3O4S2 |
| CAS# | 1257628-77-5 |
| Inchi | InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13) |
| Inchi Key | JBMKAUGHUNFTOL-UHFFFAOYSA-N |
| SMILES | C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/olverembatinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7062-Olverembatinib-chemical-structure.png |