Iptacopan
Iptacopan is a highly potent and highly selective inhibitor of factor Bwith an IC50 value of 10 nM. It also shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM. It can be used in research for complement-mediated diseases, including C3G, PNH, IgA nephropathy, and membranous nephropathy.
| Trivial name | LNP023 |
| Catalog Number | E7027 |
| Molecular Formula | C20H24O2 |
| CAS# | 1644670-37-0 |
| Inchi | InChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1 |
| Inchi Key | BFPYWIDHMRZLRN-SLHNCBLASA-N |
| SMILES | CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/iptacopan.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7027-Iptacopan-chemical-structure.png |