Cholesteryl hemisuccinate

Cholesteryl hemisuccinate is a cholesterol derivative and a potent inhibior of DNA polymerase and DNA topoisomerase with an IC50 of 2.9 μM, 6.3 μM, 25 μM for Rat DNA polymerase β, Human DNA polymerase λ and Human DNA topoisomerase I respectively. It exhibits anticancer effect due to its ability to inhibit DNA replication, repair and cell division and can be used in cancer cell growth research.

Catalog Number E6461
Molecular Formula C14H13N5O5S2
CAS# 1510-21-0
Inchi InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
Inchi Key RTXOFQZKPXMALH-GHXIOONMSA-N
SMILES C=CC1=C(N2C(C(C2=O)NC(=O)C(=NO)C3=CSC(=N3)N)SC1)C(=O)O
Size 1g
Supplier Page http://www.selleckchem.com/products/cholesteryl-hemisuccinate.html
Additional Information https://file.selleck.cn/downloads/struct/E6461-Cholesteryl-hemisuccinate-chemical-structure.png