Sulindac sulfide
Sulindac sulfide is a potent, reversible and noncompetitive inhibitor of γ42-secretase with an IC50 of 20.2 μM. It preferentially reduces Aβ42 generation, inhibits Aβ40 and Notch intracellular domain production, and can be used in Alzheimer’s disease research.
| Trivial name | cis-Sulindac sulfide |
| Catalog Number | E6426 |
| Molecular Formula | C18H14N4O2 |
| CAS# | 49627-27-2 |
| Inchi | InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22) |
| Inchi Key | VPVLEBIVXZSOMQ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/sulindac-sulfide.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E6426-Sulindac-sulfide-chemical-structure.png |