VRK-IN-1
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinase 1 (VRK1) with an IC50 of approximately 150 nM. It also facilitates H4 deacetylation (reducing H4K16 acetylation) and promotes the accumulation of DNA strand breaks while preventing progression of the DNA repair process.
| Catalog Number | E6425 |
| Molecular Formula | C18H14N4O2 |
| CAS# | 2378855-09-3 |
| Inchi | InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22) |
| Inchi Key | VPVLEBIVXZSOMQ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/vrk-in-1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E6425-VRK-IN-1-chemical-structure.png |