GSK4418959
GSK4418959 is a non-covalent, reversible, selective and orally active inhibitor of WRN helicase. It inhibits ATPase and DNA unwinding functions in an ATP-competitive manner and can be a potential therapeutic agent that can be used for the study of microsatellite instability-high (MSI-H) cancer research.
| Trivial name | IDE275 |
| Catalog Number | E6402 |
| Molecular Formula | C22H20F5N3O3 |
| CAS# | 3064599-36-3 |
| Inchi | InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1 |
| Inchi Key | OJPLJFIFUQPSJR-INIZCTEOSA-N |
| SMILES | CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/gsk4418959.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E6402-GSK4418959-chemical-structure.png |