Sivelestat sodium
Sivelestat sodium (ONO-5046, Sodium sivelestat, LY544349 sodium) is a potent, specific, and intravenously active inhibitor of neutrophil elastase with an IC50 value of 44 nm. It is a useful agent for studying the roles of neutrophil elastase in animal disease models such as emphysema, adult respiratory distress syndrome, septic shock and disseminated intravascular coagulation in COVID-19.
| Trivial name | ONO-5046, Sodium sivelestat, LY544349 sodium |
| Catalog Number | E6013 |
| Molecular Formula | C29H27F3N6O |
| CAS# | 150374-95-1 |
| Inchi | InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39) |
| Inchi Key | PHXJVRSECIGDHY-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/sivelestat-sodium.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E6013-Sivelestat-sodium-chemical-structure.png |