Sivelestat sodium
Sivelestat sodium (ONO-5046, Sodium sivelestat, LY544349 sodium) is a potent, specific, and intravenously active inhibitor of neutrophil elastase with an IC50 value of 44 nm. It is a useful agent for studying the roles of neutrophil elastase in animal disease models such as emphysema, adult respiratory distress syndrome, septic shock and disseminated intravascular coagulation in COVID-19.
| Trivial name | ONO-5046, Sodium sivelestat, LY544349 sodium |
| Catalog Number | E6013 |
| Molecular Formula | C14H16ClN3O4S2 |
| CAS# | 150374-95-1 |
| Inchi | InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20) |
| Inchi Key | JFVNFXCESCXMBC-UHFFFAOYSA-N |
| SMILES | CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/sivelestat-sodium.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E6013-Sivelestat-sodium-chemical-structure.png |