Agomelatine hydrochloride

Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. It is also a selective antagonist of 5-HT2C receptors with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. Blockade of these receptors enhances adrenergic and dopaminergic transmission in the frontocortical regions.

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Trivial name	S-20098 hydrochloride
Catalog Number	E6011
Molecular Formula	C19H31N5O2
CAS#	1176316-99-6
Inchi	InChI=1S/C19H31N5O2/c1-12(2)10-15(25)20-17-14-11-24(19(3,4)16(14)21-22-17)18(26)13-6-8-23(5)9-7-13/h12-13H,6-11H2,1-5H3,(H2,20,21,22,25)
Inchi Key	HUXYBQXJVXOMKX-UHFFFAOYSA-N
SMILES	CC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C
Size	1g
Supplier Page	http://www.selleckchem.com/products/agomelatine-hydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/E6011-Agomelatine-hydrochloride-chemical-structure.png