Agomelatine hydrochloride

Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. It is also a selective antagonist of 5-HT2C receptors with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. Blockade of these receptors enhances adrenergic and dopaminergic transmission in the frontocortical regions.

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Trivial name	S-20098 hydrochloride
Catalog Number	E6011
Molecular Formula	C22H20N2O5S
CAS#	1176316-99-6
Inchi	InChI=1S/C22H20N2O5S/c1-17(25)24(30(27,28)21-11-9-20(29-2)10-12-21)22-6-4-3-5-19(22)8-7-18-13-15-23(26)16-14-18/h3-16H,1-2H3/b8-7+
Inchi Key	OCKHRKSTDPOHEN-BQYQJAHWSA-N
SMILES	CC(=O)N(C1=CC=CC=C1C=CC2=CC=[N+](C=C2)[O-])S(=O)(=O)C3=CC=C(C=C3)OC
Size	5mg
Supplier Page	http://www.selleckchem.com/products/agomelatine-hydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/E6011-Agomelatine-hydrochloride-chemical-structure.png