Col003
Col003 is a potent inhibitor of Hsp47 that competitively binds to the collagen-binding site on Hsp47 and inhibited the interaction between Hsp47 and collagen with an IC50 of 1.8 μM. It can be used in research as a potential lead compound for the treatment of fibrosis.
| Catalog Number | E5996 |
| Molecular Formula | C21H24FN3O4.HCl |
| CAS# | 328565-16-8 |
| Inchi | InChI=1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H/t11-,16+;/m0./s1 |
| Inchi Key | IDIIJJHBXUESQI-DFIJPDEKSA-N |
| SMILES | COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/col003.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5996-Col003-chemical-structure.png |