PRDX1-IN-1
PRDX1-IN-1 is a celastrol-ligustrazine hybrid and a potent inhibitor of peroxiredoxin 1 (PRDX1) with an IC50 of 0.164 μM. It induces ROS accumulation, inhibits cancer cell growth and metastasis, and exhibits strong antitumor efficacy, making it a promising candidate for lung cancer therapy.
| Catalog Number | E5960 |
| Molecular Formula | C21H21ClN4OS·HCl |
| CAS# | 2996096-63-8 |
| Inchi | InChI=1S/C21H21ClN4OS.ClH/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21;/h1-4,11,13H,5-10,12H2,(H,23,27);1H |
| Inchi Key | NZDBKBRIBJLNNT-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54.Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/prdx1-in-1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5960-PRDX1-IN-1-chemical-structure.png |