PB94
PB94 is a potent and selective inhibitor of HDAC11 with an IC50 of 108 nM and exhibits >40-fold selectivity over other HDAC isoforms. It ameliorates neuropathic pain in mouse models and can be radiolabeled with carbon-11 as [¹¹C]PB94 for PET imaging, demonstrating significant brain uptake and potential for in vivo imaging applications.
| Catalog Number | E5948 |
| Molecular Formula | C14H21N3O2S·C4H6O4 |
| CAS# | 3032970-74-1 |
| Inchi | InChI=1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8) |
| Inchi Key | PORMUFZNYQJOEI-UHFFFAOYSA-N |
| SMILES | CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C.C(CC(=O)O)C(=O)O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/pb94.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5948-PB94-chemical-structure.png |