LXG6403
LXG6403 is a bi-thiazole potent inhibitor of LOX cellular activity with an IC50 of 1.3 μM. It exhibits anti-cancer activity by remodeling the extracellular matrix, enhancing chemotherapy penetration, inducing ROS generation, and promoting DNA damage-mediated cell death to overcome chemotherapy resistance in triple-negative breast cancer.
| Catalog Number | E5913 |
| Molecular Formula | C34H57N2O4.Br |
| CAS# | 315705-04-5 |
| Inchi | InChI=1S/C34H57N2O4.BrH/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36;/h25-32H,6-22H2,1-5H3;1H/q+1;/p-1/t25-,26+,27- ,28-,29-,30-,31-,32-,33-,34-;/m0./s1 |
| Inchi Key | VEPSYABRBFXYIB-PWXDFCLTSA-M |
| SMILES | CC(=O)OC1CC2CCC3C(C2(CC1N4CCCCC4)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-] |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/lxg6403.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5913-LXG6403-chemical-structure.png |