FEN1-IN-1
FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg²⁺ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.
| Catalog Number | E5886 |
| Molecular Formula | C37H48N4O5 |
| CAS# | 824983-91-7 |
| Inchi | InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2 ,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1 |
| Inchi Key | KJHKTHWMRKYKJE-SUGCFTRWSA-N |
| SMILES | CC1=C(C(=CC=C1)C)OCC(=O)NC(CC2=CC=CC=C2)C(CC(CC3=CC=CC=C3)NC(=O)C(C(C)C)N4CCCNC4=O)O |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/fen1-in-1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5886-FEN1-IN-1-chemical-structure.png |