LYG-409
LYG-409 is a potent, selective, and orally bioavailable degrader of GSPT1, with a DC50 of 7.87 nM. It exhibits strong antiproliferative activity in KG-1 cells with an IC50 of 9.50 nM and demonstrates significant antitumor efficacy in vivo in models of acute myeloid leukemia and prostate cancer.
| Catalog Number | E5877 |
| Molecular Formula | C19H22N8O6S2.H2SO4 |
| CAS# | 3053857-55-6 |
| Inchi | InChI=1S/C19H22N8O6S2.H2O4S/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28;1-5(2,3)4/h2-3,8,13,17,20,28H,4-7H2,1H3,(H2,21,22)(H,23,29)(H,3 1,32);(H2,1,2,3,4)/b20-11?,24-12+;/t13-,17-;/m1./s1 |
| Inchi Key | LZOLCSVRFKCSEM-VIPNVKMVSA-N |
| SMILES | CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)CN4C=CC(=N)N4CCO)C(=O)O.OS(=O)(=O)O |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/lyg-409.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5877-LYG-409-chemical-structure.png |