LL-K12-18

LL-K12-18 is a potent dual-site molecular glue that enhances CDK12-DDB1 complex formation, promoting cyclin K degradation with an EC50 of 0.37 nM. It also demonstrates strong inhibition of gene transcription and anti-proliferative effects in tumor cells, exhibiting significant potential in cancer research.

Price Not Available 1g LL-K12-18 Supplier Page

Catalog Number	E5876
Molecular Formula	C15H18N4O4S
Inchi	InChI=1S/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3/t7-,8-,10-,11-/m1/s1
Inchi Key	MRMBZHPJVKCOMA-YJFSRANCSA-N
SMILES	CC1C2C(C(=O)N2C(=C1SC3CN4C=NC=[N+]4C3)C(=O)[O-])C(C)O
Size	1g
Supplier Page	http://www.selleckchem.com/products/ll-k12-18.html
Additional Information	https://file.selleck.cn/downloads/struct/E5876-LL-K12-18-chemical-structure.png