LL-K12-18

LL-K12-18 is a potent dual-site molecular glue that enhances CDK12-DDB1 complex formation, promoting cyclin K degradation with an EC50 of 0.37 nM. It also demonstrates strong inhibition of gene transcription and anti-proliferative effects in tumor cells, exhibiting significant potential in cancer research.

Price Not Available 25mg LL-K12-18 Supplier Page

Catalog Number	E5876
Molecular Formula	C30H31F3N8O
Inchi	InChI=1S/C30H31F3N8O/c1-19-4-7-23(13-27(19)39-29-36-10-8-26(38-29)22-14-34-18-35-15-22)37-28(42)20-5-6-21(25(12-20)30(31,32)33)16-41-11-9-24(17-41)40(2)3/h4-8,10,12-15,18,24H,9,11,16-17H2,1-3H3,(H,37, 42)(H,36,38,39)/t24-/m0/s1
Inchi Key	ZGBAJMQHJDFTQJ-DEOSSOPVSA-N
SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC(=C(C=C2)CN3CCC(C3)N(C)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CN=C5
Size	25mg
Supplier Page	http://www.selleckchem.com/products/ll-k12-18.html
Additional Information	https://file.selleck.cn/downloads/struct/E5876-LL-K12-18-chemical-structure.png