ATX968
ATX968 (DHX9-IN-2) is a potent, selective, and orally bioavailable inhibitor of DHX9 helicase with an IC50 of 8 nM. It induces strong and sustained tumor growth inhibition or regression in MSI-H/dMMR colorectal cancer (CRC) xenograft models.
| Trivial name | DHX9-IN-2 |
| Catalog Number | E5836 |
| Molecular Formula | C13H12F2N6O |
| CAS# | 2973395-71-8 |
| Inchi | InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 |
| Inchi Key | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/atx968.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5836-ATX968-chemical-structure.png |