MASM7
MASM7 is an activator of mitofusins that promotes mitochondrial fusion through mitofusins. It increases mitochondrial AR in MEFs in a concentration-dependent manner, with an EC50 value of 75 nM. MASM7 also directly binds to the HR2 domain of MFN2 with a dissociation constant (Kd) of 1.1 μM, effectively activating MFN2 or MFN to induce fusion.
| Catalog Number | E5826 |
| Molecular Formula | C23H23ClN2O5S |
| CAS# | 920868-45-7 |
| Inchi | InChI=1S/C23H23ClN2O5S/c1-14-21(25-23(29)30-15(2)18-5-3-4-6-19(18)24)22(31-26-14)17-9-7-16(8-10-17)13-32-12-11-20(27)28/h3-10,15H,11-13H2,1-2H3,(H,25,29)(H,27,28) |
| Inchi Key | LLIFMNUXGDHTRO-UHFFFAOYSA-N |
| SMILES | CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/masm7.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5826-MASM7-chemical-structure.png |