YB-3-17
YB-3−17 is a dual-target compound that effectively and selectively inhibits mTOR with an IC50 of 0.22 nM, while promoting GSPT1 degradation with an IC50 of 5 nM, leading to substantial tumor growth inhibition both in vitro and in vivo. It also exhibits significant antiproliferative activity in glioblastoma models.
| Catalog Number | E5815 |
| Molecular Formula | C21H25ClN2O3.2HCl |
| CAS# | 2940242-88-4 |
| Inchi | InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H |
| Inchi Key | PGLIUCLTXOYQMV-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/yb-3-17.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5815-YB-3-17-chemical-structure.png |