Ro 67-7476
Ro 67-7476 is a potent positive allosteric modulator of mGluR1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC50 of 60.1 nM. Ro 67-7476 is a potent P-ERK1/2 agonist?and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM).
| Catalog Number | E5810 |
| Molecular Formula | C25H34O6 |
| CAS# | 298690-60-5 |
| Inchi | InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21+,22+,23-,24-,25+/m0 /s1 |
| Inchi Key | VOVIALXJUBGFJZ-VXKMTNQYSA-N |
| SMILES | CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ro-67-7476.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e5810-ro-67-7476-chemical-structure-tube.png |