Laduviglusib trihydrochloride

Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy.

Price Not Available 5mg Laduviglusib trihydrochloride Supplier Page

Trivial name	CHIR-99021 trihydrochloride, CT99021 trihydrochloride
Catalog Number	E5780
Molecular Formula	C20H17ClF4N4O4S
CAS#	1782235-14-6
Inchi	InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1
Inchi Key	XEAOPVUAMONVLA-QGZVFWFLSA-N
SMILES	C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl
Size	5mg
Supplier Page	http://www.selleckchem.com/products/laduviglusib-trihydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/E5780-Laduviglusib-trihydrochloride-chemical-structure.png