Exatecan
Exatecan (DX-8951), is a water-soluble derivative of camptothecin. It acts as an inhibitor of DNA topoisomerase I with an IC50 value of 1.906 μM. It demonstrates potent antitumor effects and triggers apoptotic cell death after treatment in human pancreatic cancer cells.
| Trivial name | DX-8951 |
| Catalog Number | E5775 |
| Molecular Formula | C10H8F2N4O |
| CAS# | 171335-80-1 |
| Inchi | InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17) |
| Inchi Key | POGQSBRIGCQNEG-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)F)CN2C=C(N=N2)C(=O)N)F |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/exatecan.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5775-Exatecan-chemical-structure.png |