JNJ-75276617
JNJ-75276617 (Bleximenib, Menin-MLL inhibitor 24) is an orally bioavailable, potent inhibitor of menin targeting the menin-KMT2A selective protein-protein interaction. It also acts as an inhibitor of menin-mixed-lineage leukemia 1 (menin-MLL). JNJ-75276617 displays highly potent antiproliferative activity across several acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cell lines and patient samples.
| Trivial name | Bleximenib, Menin-MLL inhibitor 24 |
| Catalog Number | E4994 |
| Molecular Formula | C10H13FN5O7P |
| CAS# | 2654081-35-1 |
| Inchi | InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1 |
| Inchi Key | GIUYCYHIANZCFB-FJFJXFQQSA-N |
| SMILES | C1=NC2=C(N=C(N=C2N1C3C(C(C(O3)COP(=O)(O)O)O)O)F)N |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/jnj-75276617.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4994-JNJ-75276617-chemical-structure.png |