Oclacitinib
Oclacitinib(PF-03394197), an inhibitor of JAK is highly potent at inhibiting JAK1 with an IC50 value of 10 nM, respectively. Oclacitinib is highly potent against the JAK1 enzyme, displaying a 1.8-fold selectivity for JAK1 vs. JAK2 and a 9.9-fold selectivity toward JAK1 vs. JAK3.
| Trivial name | PF-03394197 |
| Catalog Number | E4971 |
| Molecular Formula | C16H21Cl2N3O2.HCl |
| CAS# | 1208319-26-9 |
| Inchi | InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H |
| Inchi Key | ZHSKUOZOLHMKEA-UHFFFAOYSA-N |
| SMILES | CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/oclacitinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4971-Oclacitinib-chemical-structure.png |