HS-10296 hydrochloride

HS-10296 hydrochloride(Almonertinib (hydrochloride), HS-10296 HCl) is an irreversible, third-generation inhibitor of EGFR tyrosine kinase that demonstrates high selectivity for EGFR-sensitizing mutations, T790M resistance mutation. It exhibits inhibitory activity against T790M, T790M/L858R, and T790M/Del19, with IC50 of 0.37 nM, 0.29 nM, and 0.21 nM, respectively. It also exhibits anti-tumor activity.

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Trivial name	Almonertinib (hydrochloride), HS-10296 HCl
Catalog Number	E4886
Molecular Formula	C17H24N4O2S2
CAS#	2134096-03-8
Inchi	InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22)
Inchi Key	OUSFTKFNBAZUKL-UHFFFAOYSA-N
SMILES	CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
Size	5mg
Supplier Page	http://www.selleckchem.com/products/hs-10296-hydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/E4886-HS-10296-hydrochloride-chemical-structure.png