Rolapitant hydrochloride hydrate
Rolapitant hydrochloride hydrate(SCH619734 hydrochloride hydrate) is a long-acting, extremely selective antagonist of the Nk-1 receptor antagonist (NK-1RA) with antiemetic activity. It significantly penetrates the central nervous system (CNS) and used clinically to prevent chemotherapy-induced nausea and vomiting (CINV) in cancer patients undergoing high and moderate emetogenic chemotherapy.
Trivial name | SCH619734 hydrochloride hydrate |
Catalog Number | E4853 |
Molecular Formula | C21H27N7O3 |
CAS# | 914462-92-3 |
Inchi | InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 |
Inchi Key | KGPGFQWBCSZGEL-ZDUSSCGKSA-N |
SMILES | CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N |
Size | 100mg |
Supplier Page | http://www.selleckchem.com/products/rolapitant-hydrochloride-hydrate.html |
Additional Information | https://file.selleck.cn/downloads/struct/E4853-Rolapitant-hydrochloride-hydrate-chemical-structure.png |