BML-284
BML-284 (Wnt Agonist) is a potent and cell-permeable activator of Wnt signaling that induces TCF-dependent transcriptional activity with an EC50 value of 0.7 µM. BML-284 also acts as an agonist of β-catenin that effectively activates direct Wnt-β-catenin signaling to induce adipocyte dedifferentiation while circumventing the apoptotic effect in the hypertonic treatment.
| Trivial name | Wnt Agonist |
| Catalog Number | E4800 |
| Molecular Formula | C22H16N4O3 |
| CAS# | 853220-52-7 |
| Inchi | InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) |
| Inchi Key | FHYUGAJXYORMHI-UHFFFAOYSA-N |
| SMILES | C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/bml-284.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4800-BML-284-chemical-structure.png |