GSK-J4
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A that ameliorates experimental autoimmune encephalomyelitis (EAE). It is also an inhibitor of TNF-α production, with an IC50 of 9 μM. It shows potential as a treatment for inflammatory and autoimmune disorders.
| Catalog Number | E4794 |
| Molecular Formula | C23H27N7O3S2 |
| CAS# | 1373423-53-0 |
| Inchi | InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) |
| Inchi Key | LHNIIDJUOCFXAP-UHFFFAOYSA-N |
| SMILES | CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/gsk-j4.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4794-GSK-J4-chemical-structure.png |