Nigericin
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, which causes the efflux of potassium from the cell and, thus, influences the mitochondria membrane potential. It also induces pyroptosis in macrophages by activating NLRP3 inflammasome.
| Catalog Number | E4788 |
| Molecular Formula | C24H23FN4O3 |
| CAS# | 28380-24-7 |
| Inchi | InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30) |
| Inchi Key | FDLYAMZZIXQODN-UHFFFAOYSA-N |
| SMILES | C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/nigericin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4788-Nigericin-chemical-structure.png |