DMB
DMB (GLP-1R agonist 2, Compound 2) is an agonist of the GLP-1 receptor (GLP-1R) with a Ki of 13.25 µM. It activates GLP-1R by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues. DMB attenuates transient focal cerebral ischemia injury and inhibits neuronal apoptosis induced by MCAO.
| Trivial name | GLP-1R agonist 2 |
| Catalog Number | E4779 |
| Molecular Formula | C21H20N4O3 |
| CAS# | 281209-71-0 |
| Inchi | InChI=1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26) |
| Inchi Key | INVTYAOGFAGBOE-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/dmb.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4779-DMB-chemical-structure.png |